EUT-DC3: Nutrition and health

Supervisors: Dr. Thi Thu Hao Van, Dr. Daniel Dias, Dr. Josep Mª Del Bas and Dr. Jordi Mayneris Perxachs.

 

Project 1: Understanding the role of gut-brain axis

Information from large-scale human cohorts (n=300 and n=1030) with a wide range of age (from 23 to 99 years old) already characterized and to be further characterized by omics profiling will be used to study metabolic pathways affected by ageing, with special attention on gut microbiome. Results will be translated to preclinical models by means of xenotransplantation or targeted microbiota manipulation to underscore the molecular mechanisms linking microbiome ageing with alterations in key overarching physiological processes that take place during the ageing process. Information obtained from these approaches by next generation sequencing and downstream RNA-seq, metagenomics, and genomic bioinformatics analysis will be further used to isolate and characterize new probiotics against ageing-related diseases.

Project 2: Role of microbiota to improve nutritional strategies for a healthier ageing

Information from large-scale human cohorts (n=300 and n=1030) with a wide range of age (from 23 to 99 years old) already characterized and to be further characterized by omics profiling will be used to study metabolic pathways affected by ageing, with special attention on gut microbiome. The information provided by these analyses will be further used in preclinical models of ageing to identify and design new oral treatments, including probiotics, postbiotics, or other nutritional and pharmacological approaches, targeting gut microbiota to restore physiological processes that are dysregulated during the ageing process.

Project 3: Omics-based approach for understanding ageing

Information from large-scale human cohorts (n=300 and n=1030) with a wide range of age (from 23 to 99 years old) already characterized and to be further characterized by omics profiling will be used to discover associations between gut microbiome, metabolic elements of the gut-brain axis, and cognitive decline. Key elements of the microbiome affected by ageing will be studied in preclinical models to underscore the alterations on the gut-brain axis involved in ageing-related cognitive decline. Information obtained from these approaches by next generation sequencing and downstream RNA-seq, metagenomics, and genomic bioinformatics analysis will be further used to isolate and characterize new psycho-biotics against cognitive and behavioral alterations associated with ageing.

Reference

EUT-DC3

Research Areas

Metabolism, Molecular Biology, Applied science

Research Host

Eurecat Centre Tecnològic de Catalunya

PhD awarding institution/s

University of Girona, Spain and RMIT University, Australia

Location

Spain

Status

Open Position

RMIT University

Other Positions

Supervisors

Dr. Malte Wagenfeld and Prof. Regina Bernhaupt

PhD awarding institution/s

Eindhoven University of Technology (TU/e), Netherlands and RMIT University, Australia

Location

Netherlands

Status

Open Position

Supervisors

Dr. Carmen Mendoza Arroyo, Prof. Esther Charlesworth and Dr. Apen Ruiz Martinez (Project 1)

PhD awarding institution/s

Universitat Internacional de Catalunya (UIC) and RMIT University

Location

Spain

Status

Open Position

Supervisors

Prof. Jesus Cerquides and Associate Prof. Jeffrey Chan and Dr. Azadeh Alavi.

PhD awarding institution/s

Autonomous University of Barcelona (UAB), Spain and RMIT  University, Australia

Location

Spain

Status

Open Position

RMIT and many of the REDI partners are HSR4R certified
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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034328.

Results reflect the author’s view only. The European Commission is not responsible for any use that may be made of the information it contains

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